Wegovy® (semaglutide) injection 2.4 mg is an injectable prescription medicine used with a reduced calorie diet and increased physical activity, to reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight and that may help adults and children aged 12 years and older with obesity, or some adults with overweight who also have weight-related medical problems, to help them lose excess body weight and keep the weight off.

Wegovy®, along with a reduced calorie diet and increased physical activity, is used to help children aged 12 years and older with obesity to lose excess body weight and keep it off.

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Common Side Effects of Wegovy®

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What might you expect?

The most common side effects of Wegovy® may include:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Stomach (abdomen) pain
  • Headache
  • Tiredness (fatigue)
  • Upset stomach
  • Dizziness
  • Feeling bloated
  • Belching
  • Low blood sugar in people with type 2 diabetes
  • Gas
  • Stomach flu
  • Heartburn
  • Runny nose or sore throat

Pay attention to how you’re feeling and talk with your health care professional about any side effect that does not go away or bothers you.

The use of Wegovy® has been associated with gastrointestinal (GI) side effects, which are sometimes severe.* Wegovy® is not recommended in patients with severe gastroparesis. Nausea was the most frequently reported symptom. Nausea was generally mild or moderate and transient. Most occurrences of nausea did not lead to permanent discontinuation of Wegovy®.

*In medical studies, gastrointestinal side effects were more common in people taking Wegovy® than in people taking placebo, and people taking Wegovy® were more likely to stop treatment because of these side effects.

Talk it out with your care team

Let your care team know about any side effect that bothers you or does not go away. Everyone is different, so they can help you determine the best course of action. If you experience nausea, talk with your health care professional and they will offer guidance, which may include some of these general tips.

Tips for managing nausea

Eat bland, low-fat foods, like crackers, toast, and rice

Go outdoors for fresh air

Eat foods that contain water, like soups and gelatin

Eat more slowly

Avoid lying down after you eat

Avoid greasy foods

Discuss all possible side effects of Wegovy® with your health care professional.

See the Medication Guide.

Any questions?

While your health care professional is always the best source of information about your care and medication, you can also check out our FAQs page for some quick information about Wegovy®.

Get answers 
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Take your next steps with support

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WeGoTogether® partners with you while you're taking Wegovy®. We'll be there for you along your Wegovy® path with your choice of support features, like a dedicated Health Coach and your own portal to track your medicine.

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Call 1-833-4-WEGOVY (1-833-493-4689) between 9:00 AM and 9:00 PM ET, Monday–Friday.

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